KMID : 0191120110260040528
|
|
Journal of Korean Medical Science 2011 Volume.26 No. 4 p.528 ~ p.533
|
|
B-cell Complement Dependent Cytotoxic Crossmatch Positivity is an Independent Risk Factor for Long-term Renal Allograft Survival
|
|
Hwang Hyeon-Seok
Yoon Hye-Eun Choi Bum-Soon Oh Eun-Jee Kim Ji-Il Moon In-Sung Kim Yong-Soo Yang Chul-Woo
|
|
Abstract
|
|
|
The clinical significance of positive B-cell complement-dependent cytotoxicity crossmatching (B-CDC) in renal transplant recipients remains unclear. We reviewed 20 recipients with isolated B-CDC positivity at the time of transplantation. We compared the clinical characteristics, acute rejection and long-term graft survival between positive and negative B-CDC patients (n = 602). The number of retransplant recipients and positivity for T- and B-flowcytometric crossmatch was greater in positive B-CDC patients than in negative B-CDC patients. The overall acute rejection rate of positive B-CDC patients was significantly higher (P < 0.001), and Banff grade II or III cellular rejection was more frequently observed in positive B-CDC patients (P = 0.037). Compared with negative B-CDC patients, acute cellular rejection as a cause of graft loss was more prevalent (P = 0.020) and rescue rejection therapy was more frequently needed in positive B-CDC patients (P = 0.007). The allograft survival rate of positive B-CDC patients was significantly lower than that of negative B-CDC patients (P < 0.001), and B-CDC positivity independently increased the risk of allograft failure 2.31-fold (95% CI 1.15-4.67; P = 0.019) according to multivariate analysis. In conclusion, isolated B-CDC positivity is an independent long-term prognostic factor for allograft survival.
|
|
KEYWORD
|
|
B-cell, Cytotoxicity Tests, Immunologic, Kidney Transplantation
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|